A Clinically Relevant Unilateral Rat Model of Parkinsonian Akinesia
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چکیده
منابع مشابه
A Clinically Relevant Unilateral Rat Model of Parkinsonian Akinesia
In transplantation research on Parkinson's disease, behavioral evidence of graft-specific improved function is as necessary as anatomical or chemical data in evaluating the success of the procedure. The circling model of Ungerstedt has been widely adopted to provide such evidence, in part because it is so convenient and (relative to primate models) inexpensive. In this model 6-hydroxydopamine (...
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We have studied the effects of stimulating the pedunculopontine nuclei through a fully implanted macroelectrode with a s.c. implantable pulse generator whose parameters can be programmed telemetrically, in a macaque before and after inducing Parkinsonian akinesia with MPTP. Our results show that in the normal monkey high frequency stimulation of the pedunculopontine nuclei reduces motor activit...
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.............................................................................................................................. ii Co-Authorship Statement................................................................................................... iii Acknowledgments.............................................................................................................. iv List of Tab...
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ژورنال
عنوان ژورنال: Journal of Neural Transplantation and Plasticity
سال: 1992
ISSN: 0792-8483
DOI: 10.1155/np.1992.332